|
KMID : 0370220110550050391
|
|
Yakhak Hoeji
2011 Volume.55 No. 5 p.391 ~ p.397
|
|
|
Sodium Metaarsenite (KML001) Induces G1 Phase Arrest in HCT116 Colorectal Cancer Cells
|
|
Hong Yun-Kyung
Kim Sun-Mi
Lee Seung-Hoon
Kang Jae-Seon
Hong Yong-Geun
|
|
|
Abstract
|
|
|
|
KML001 reduced the proliferation of HCT116 cells in a concentration- and time-dependent manner without change of cell viability. Beclin-1 expression was significantly attenuated by KML001 (P<0.05), but no significant changes were observed in KML001-treated cells. The number of cells in G1 phase was increased 48 hr after KML001 treatment. Furthermore, a dramatic reduction in the frequency of beating and the number of embryoid bodies of the cells was noted after treatment. Taken together, KML001 suppresses the proliferation of HCT116 cells, which might be due to G1 phase arrest.
|
|
|
KEYWORD
|
|
|
KML001, colorectal cancer cell, G1 phase arrest, cardiac toxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|